Evidence-based diagnosis of familial non-X-linked dilated cardiomyopathy. Prevalence, inheritance and characteristics
نویسندگان
چکیده
منابع مشابه
Evidence-based diagnosis of familial non-X-linked dilated cardiomyopathy. Prevalence, inheritance and characteristics.
AIMS To assess the prevalence of familial non-X-linked dilated cardiomyopathy, to diagnose early asymptomatic cases evaluate inheritance and characterize clinical phenotypes. METHODS AND RESULTS We screened 472 relatives of 104 consecutive patients diagnosed with dilated cardiomyopathy; males with X-linked dilated cardiomyopathy were excluded based on systematic immunohistochemical and molecu...
متن کاملX-linked dilated cardiomyopathy.
Background. X-linked cardiomyopathy (XLCM) is a rapidly progressive primary myocardial disorder presenting in teenage males as congestive heart failure. Manifesting female carriers have later onset (fifth decade) and slower progression. The purpose of this study was to localize the XLCM gene locus in two families using molecular genetic techniques. Methods and Results. Linkage analysis using 60...
متن کاملGuidelines for the diagnosis and management of familial dilated cardiomyopathy.
Dilated cardiomyopathy (DCM) is a myocardial disorder that is a major cause of heart failure and death. Recent data indicate that genetic factors are important in the pathogenesis of DCM and may account for at least one-third of cases of "idiopathic" DCM. Apart from a positive family history, there are no specific clinical manifestations that reliably distinguish familial from non-familial DCM,...
متن کاملIdiopathic dilated cardiomyopathy: familial prevalence and HLA distribution.
OBJECTIVES To compare HLA distribution in familial and non-familial dilated cardiomyopathy, because a serum marker that could identify families at risk of developing dilated cardiomyopathy should be of use in screening for the disease. PATIENTS 100 patients with dilated cardiomyopathy. METHODS 200 first degree relatives from 56 of the proband families were screened for dilated cardiomyopath...
متن کاملFamilial dilated cardiomyopathy.
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2001
ISSN: 0195-668X
DOI: 10.1053/euhj.2000.2171